Two costly mistakes from Inter players proved decisive at the Bernabéu, though the Nerazzurri pushed hard for a leveller that never came.
Aston Villa claimed a 3-2 victory away at Club Brugge KV in their UEFA Champions League league stage opener at the Jan Breydel Stadion on Tuesday.
Chicago Fire welcome Inter Miami to Soldier Field on Thursday, with five points separating third from second in Major League Soccer's Regular Season.
Real Madrid host Inter in the UEFA Champions League League Stage on Tuesday, with both sides yet to register a point in the competition.
Club Brugge KV host Aston Villa in the UEFA Champions League League Stage on Tuesday, with the two sides separated by contrasting recent form.
