Two costly mistakes from Inter players proved decisive at the Bernabéu, though the Nerazzurri pushed hard for a leveller that never came.
Chicago Fire welcome Inter Miami to Soldier Field on Thursday, with five points separating third from second in Major League Soccer's Regular Season.
Real Madrid host Inter in the UEFA Champions League League Stage on Tuesday, with both sides yet to register a point in the competition.
The Republic of Ireland forward, handed his Tottenham debut by José Mourinho in 2019, came off the bench to settle a dramatic La Liga contest at the Estadio de La Cartuja.
